chemical composition of Seroquel drugor Seroquel Prolong depends primarily on the release form of the drug.As indicated above a tablet formulations may contain 25, 50, 100, 150, 200, 300 or 400 mg. quetiapine (active substance).
As part of the drug Seroquel are also present, such as the auxiliary connection: calcium phosphate, povidone, carboxymethyl starch, microcrystalline cellulose, lactose monohydrate, sodium carboxymethyl and magnesium stearate .
film coated tablet contains macrogol 400, titanium dioxide , and hypromellose , and in some dosage forms of the drug present dyes, for example, yellow or red iron oxide.
As part of the active compound in addition quetiapine drug Seroquel Prolong contains such ancillary components such as: lactose monohydrate, microcrystalline cellulose, sodium dihydrate, magnesium stearate , and Valium .Tablet film coating contains titanium dioxide, macrogol, yellow or red iron oxide and hypromellose.
Quetiapine film-coated tablets are not only on the number contained in the composition of their drug compounds, but also in color.The manufacturer produces tablets of pink color - 25 mg. quetiapine (. 10 pieces in blister, 3 or 6 blisters per pack), yellow - 100 mg. quetiapine (10 pieces in blister, 3.6 or 9 blisters in the package.) And White - 200 mg. quetiapine (10 pcs. In blister, 3.6 or 9 blister pack).
addition, one packaging drug may be a combination of different forms of drug release, i.e.6 tablets contain 25 mg, 3 -. 100 mg.and 1 - 200 mg.On one side coated tablets engraved, which indicates the amount of the drug compound contained in the composition of some form of release of the drug - Seroquel 25, Seroquel WO and Seroquel 200.
drug Seroquel Prolong release in tablet form.Depending on the shape of the drug release at a special coated film coated oblong and biconvex tablet engraved the drug can be applied, which corresponds to the number quetiapine , for example, XR50, XR150, XR200, XR300 and XR400.Typically, in one blister pack contains 10 tablets of the drug, as in a carton - 6 blisters.
Both drugs belong to antipsihotropnym drugs have on the body and neuroleptic exposure .
Since both drugs are a group atypical antipsychotics , they exhibit an affinity high relative to serotonin receptors class 5HT2 , compared with dopamine brain receptors D1 andD2 .Similar properties of drugs is shown in relation to adrenergic and histamine receptors .
During research the affinity of both drugs with benzodiazepine and cholinergic muscarinic receptors been identified.When carrying out the standard medical tests show their products antipsychotic properties. Seroquel Prolong, and Seroquel causes a not expressed catalepsy , which entails blocking dopamine D2 receptors.
Further there selective decrease in the activity of dopaminergic neurons in the mesolimbic A10 compared with those involved in motor function nigrostriatal neurons .When using both drugs in the blood does not increase the level of prolactin . As a result of research experts have discovered the ability of these drugs to deal with the symptoms and manifestations of schizophrenia .
When oral drugs drug compounds, their constituent, quickly absorbed into the stomach e, and then actively metabolized by the liver .It is worth noting that on the bioavailability of quetiapine not affect food, so both drugs can be taken regardless of meals.
As Seroquel Prolong, and Seroquel are derived from the human body with feces , and urine .
These drugs are indicated for:
Seroquel Prolong used for preventive purposes, such as to prevent relapse schizophrenic fits in stable patients and bipolar disorders in patients who have previously successfully passed courses of treatment quetiapine .In addition, the drug often include complex treatment of patients with suboptimal response to monotherapy using antidepressants .
Both drugs are contraindicated in the presence of patients are hypersensitive to this or that constituent components of the chemical composition of the drugs, as well as lactase deficiency or galactose intolerance , when malabsorption glucose-galaktoznoy.
In addition, both drugs are contraindicated for children under 18 years.Seroquel Prolong, like Seroquel should be taken with extreme caution in elderly patients, people suffering cerebrovascular and cardiovascular ailments or positioned to hypotension , as well as those categories of patients with a history describes the risks of seizures, liver failure, aspiration pneumonia and stroke .
The most common side effects of Seroquel and Seroquel Prolong are the following:
often in the first few weeks of using drugs, patients gain weight.Quite rare, but when taking these drugs may experience such side effects like: seizures, priapism, neuroleptic syndrome, impaired consciousness, dystonia, vegetative sosudnye disorders neutropenia, akathisia, and leukopenia .With long-term use of the drug may develop tardive dyskinesia .
Seroquel Prolong should be taken on an empty stomach, the tablet does not chew or crush.The dosage and duration of treatment with the drug depends on type and severity of the disease, and, in addition, one should consider the patients' health status.In the treatment of schizophrenia , as well as bipolar disorder should take the medicine according to the following schedule:
Optimal recommended daily dosage of the drug in 600 mg.It can be increased to 800 mg.in the case of acute medical necessity.
During treatment depression Seroquel Prolong take as follows:
daily recommended dosage of medication is 300 mg.It can be increased to 600 mg.medical indications and in case of a normal patient tolerability of the drug.As a preventive measure Seroquel Prolong take the night within an equal dose of 300-800 mg.
In the combined therapy with suboptimal response patients for treatment with antidepressants drug taking 50 mg.the first two days, followed by 150 mg.for another four days.
in accordance with the instructions on the drug Seroquel taken twice a day.Medication regimen, as well as the duration of treatment depends on the variety of diseases and conditions of the patient.
the treatment of schizophrenia , and drug psychoses take:
recommended daily dosage of the drug can vary from 150 to 750 mg.
the treatment biopolyarnyh disorders , and manic-depressive states are taking Seroquel as follows:
gradually built up a therapeutic dose of the drug and the sixth day can reach 800 mg.
should be noted that in compliance with the recommendations on the admission of both drugs, drug overdose cases are rare.However, in some cases, the effects of overdose were so incompatible with the life of the patient, resulting in death or coma .
Exceeding the daily doses of drugs may experience symptoms such as: drowsiness, reduced pressure, excessive sedation , and besides, tachycardia. In severe intoxication symptomatic treatment, as well as measures aimed at maintaining cardiovascular and respiratory systems of the human body .
Increasing the concentration quetiapine , and, consequently, increasing the efficiency of both drugs may occur while taking Seroquel Prolong, and Seroquel with antibiotics , belonging to the group macrolides , as well as with azole antifungal agents .Adjustment of the dosing regimen may also require the simultaneous use of drugs with medicinal products containing a part of phenytoin or designed to induce hepatic enzymes , for example, carbamazepine.
supply of pharmacies by prescription only.
Store Seroquel Prolong, and Seroquel can be at a maximum of 30 ° C, while the reach of children.
When transferring patients to the drug Seroquel Seroquel Prolong use the same daily dosage, although reduced number of medication.However, in some cases, you may require a dosage adjustment, as well as the plan of taking the pills.When using both drugs in the treatment of elderly patients should be started at a reduced daily dose (25 mg.).
Because among the side effects of both drugs present drowsiness should not drive a vehicle or operate potentially dangerous machinery units and during treatment with these agents.
WorthIt noted that the main analogue of Seroquel Seroquel Prolong considered and vice versa.However, the list of similar drugs that converge in their structure and mode of action with both drugs appear:
As a rule, experts do not recommend taking both drugs during pregnancy , since it is not known consequences of fetal development and maternal health quetiapine .However, in cases where the expected benefits outweigh the possible risk of drugs used in the therapeutic treatment under close medical supervision.
When receiving drugs breastfeeding should be discontinued.
The forums can be found a variety of responses taking drugs Seroquel and Seroquel Prolong, because people's opinions are divided.Some praise these drugs, and others - on the contrary, negative and expressed about their efficiency as well as cost.
Therefore, although many patients leave positive feedback about Seroquel Prolong, and Seroquel, a considerable number of patients as the negative side of both drugs mark a vast list of side effects, as well as too "soothing" and absolutely not the active state when they are used.
Buy both drugs can be in pharmacies by prescription.It should be noted that these drugs are not cheap, for example, the average price Seroquel Prolong 300 mg.(60 tablets in one package) up to 1100 rubles.